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This can be coupled to research indicating that activities of the main neuroprotectant antioxidant enzymes catalase and glutathione peroxidase have been found to be deficient in patients suffering from depression (Bilici et al., 1996

Additionally, pyridoxine (B6), folate (B9), and cobalamin (B12) are indispensable coenzymes for the methylation of homocysteine to methionine, a process critical to nervous system function

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Gastroenterology 135 , 17511760 (2008)

J Clin Med, 2023, 12(4)

and participates in the action of serotonin, a neurotransmitter known to control mood and appetite