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Chanas et al., 2002

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Ozone therapy once weekly to enhance follicular oxygenation, reduce microbial biofilm, and support immune re-regulation at the site of auto-reactivity

The involved signaling pathways include increased pAMPK, SIRT1, fibroblast growth factor-21, and decreased ChREBP

A significant reduction in pro-inflammatory molecules, including C-reactive protein (CRP), TNF- , and IL-6, was observed, indicating the inhibition of inflammatory pathways, likely at the level of immune system cells and adipocytes signaling

Galatti, L