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Sutcliffe S, Bradley CS, Clemens JQ et al: Urological chronic pelvic pain syndrome flares and their impact: Qualitative analysis in the mapp network

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While five of these studies showed beneficial effects on depression symptoms and measured improvements using a depression scale, the other three showed no significant impact on depression

256 Another study revealed elevated levels of p53 and proapoptotic proteins, including caspase-3, caspase-8, Bax, and Fas, in spinal motor neurons from individuals with ALS, whereas p53 levels were not altered in neurons of the motor cortex