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Epidemiological studies have demonstrated that only about 30% of heavy drinkers develop advanced ALD, suggesting alcohol dependence is not the prerequisite for the development of ALD [134]

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Leukocytes may release oxidants during phagocytosis that cause oxidative stress to the erythrocytes

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The article says prospective human data are limited, and that preclinical and animal studies have raised theoretical concerns about effects on pancreatic and gastrointestinal development