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The appearance of wrinkles (folds, furrows, and creases) as we age is largely due to a decrease in collagen production as well as increased collagen degradation

Clinical studies have shown that it has several antiaging and cardio- and neuro-protective properties, and can also alleviate osteoarticular, urologic, and menopause-related discomfort.60 The extract has also been found to have a photoprotective, modulating effect on skin pigmentation.61 Several RCTs evaluating the use of French maritime pine bark extract have shown a significant reduction in signs of facial aging, such as wrinkles and solar lentigines,62,63 and increased levels of hyaluronan synthase and type I collagen.64 Another RCT (n=76) showed increased skin elasticity and hydration and decreased skin darkening in Asians working in highly polluted areas after treatment for 12 weeks.65 No relevant adverse effects were reported

Ingredients Copper Tripeptide-1 (individual concentration not disclosed) Acetyl Hexapeptide-8 (SYN-AKE) Palmitoyl Tripeptide-38 (Matrixyl synthe'6) Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7 (Matrixyl 3000) Acetylarginyltryptophyl Diphenylglycine (ARGIRELOX) Multiple forms of hyaluronic acid 11 amino acids Total : 45+ ingredients

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In addition, the researchers propose, other factors also may contribute, such as certain medications, minor illnesses (especially gastrointestinal conditions) and perhaps changes in the microbiome that might deplete carnitine from the body

Additionally, data regarding concomitant glucose-lowering medications were also recorded at baseline