For patients using GLP-1 agonists primarily for weight management rather than diabetes control, temporary adjustment typically poses less immediate concern regarding blood glucose levels
A 2023 conference abstract actually suggested a small beneficial effect of tirzepatide on TSH levels, though this is preliminary and needs confirming in larger studies
In combination with the restored insulin sensitivity after RYGB surgery, the increased insulin in PBH may just have tipped the balance and induced extra inhibition of beta oxidation, and as consequence increased glycolysis leading to decreased plasma glucose
van Bloemendaal L, RG IJ, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML et al
Unlike traditional one-size-fits-all therapies, personalized nanomedicine can adapt to disease heterogeneity, patient-specific pathology, and pharmacogenomic profiles, thereby improving long-term efficacy and minimizing adverse effects
Acknowledgements This research was supported by the National Key R&D Program of China (2018YFC1313304, 2018YFC1313300), National Natural Science Foundation of China (81930065, 81871951), Natural Science Foundation of Guangdong Province (2019A1515010233, 2018B030306049), Pearl River S&T Nova Program of Guangzhou (201806010002), and CAMS Innovation Fund for Medical Sciences (CIFMS) (2019-I2M-5-036)
