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Experts say this is due to increased appetite, cravings and food noise

Even modest weight reduction can yield substantial improvements: A 10% weight loss can result in up to a 50% reduction in knee pain in patients with knee osteoarthritis (Messier et al., 2013)

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We have already also shown a more standard mediation analysis that shows that actually the most explainable factor for the effect on MACE [major adverse cardiovascular events] in the select trial is inflammation

Private Research Partners: Panthera Biopartners (Enfield and Sheffield) and FutureMeds (Birmingham and Liverpool)