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Moreover, it has been hypothesized that, during sleep, the oxidative detoxification of the brain may be facilitated by uridine and glutathione (GSH), which potentiate GABAergic transmission and inhibit glutamatergic transmission, respectively (Inou et al

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The resulting inflammation creates a painful cycle where swelling leads to more impingement which causes more swelling

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Additionally, TLR4 regulates hippocampal neurogenesis and synaptic function through this pathway, and is involved in neuroinflammation and neuronal apoptosis (158)

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