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Nat Rev Immunol 21(11):739751

This review summarizes the core mechanisms of heat stress-induced liver injury, including direct damage to hepatocytes by hyperthermia, the dual regulatory role of heat shock proteins (HSPs), gut barrier damage leading to endotoxemia and systemic inflammatory response, ischemiareperfusion injury, and the involvement of various cell death modes such as apoptosis, pyroptosis, and ferroptosis

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