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10.4093/dmj.2019.0099 120 WuS.LiaoX.ZhuZ.HuangR.ChenM.HuangA.et al (2022)

Before entering the nsp12 active site, the template RNA strand undergoes disruption of RNA secondary structure and guidance between the nsp13-2 RecA domain and the 1B domain to ensure the 5 to 3 translocation direction 124