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By activating both receptors simultaneously, tirzepatide produces: More powerful appetite suppression than GLP-1 stimulation alone Greater improvements in insulin sensitivity Larger reductions in body fat, particularly visceral (abdominal) fat Faster and larger HbA1c reductions in people with type 2 diabetes This dual mechanism is the pharmacological reason tirzepatide produces greater weight loss than semaglutide in every major clinical trial conducted to date
The Wegovy SmPC notes that this delay may impact the absorption of oral medications, particularly those with a narrow therapeutic index
Those with severe hepatic impairment should avoid this medication due to insufficient safety data
Hair loss from semaglutide is usually temporary
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