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In an Alzheimers disease mouse model that overexpresses SREBF2, the brains exhibit mitophagy failure, characterized by disrupted mitochondrial recruitment of the mitophagosome synthesis machinery, despite the presence of high levels of PINK1/PRKN in the mitochondria 39,40

Ali notes that fatigue may also result from anemia or other nutritional deficiencies caused by Mounjaro-induced appetite loss, which may prevent adequate intake of protein, healthy fats, or whole grains

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