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The administration of the GSH precursor significantly delayed the disease onset in the transgenic hSOD1(G93A) mice, but without extending life span, most likely due to the inability to recover the mitochondrial GSH pool in the spinal cord [120]

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14.2 Weight Management Trial in Pediatric Patients Ages 12 and Older with Obesity SAXENDA was evaluated in a 56-week, double-blind, randomized, parallel group, placebo controlled multi-center trial in 251 pubertal pediatric patients aged 12 to 17 years, with BMI corresponding to 30 kg/m2 or greater for adults by international cut-off points1 and BMI of 95th percentile or greater for age and sex (NCT02918279)

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This resource was utilized to identify mutations within the GLO-1 gene

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Glutathione-S-transferase (GST) The spontaneous glutathione-s-transferase activity in the kidney of mice was estimated to be 4.55 0.13 nmol/mg protein and treatment of mice with hesperidin increased this activity significantly when compared to non-drug treated control ( Table 2 )

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