2024 Jan-Feb 01;32(1):83-90
Scheduled Discussion Topics At your next regular appointment, discuss weight loss that has stalled for more than four weeks despite protocol adherence, persistent side effects that interfere with quality of life, questions about dose escalation timing, or interest in adding complementary medications or interventions
providers often finalize maintenance dose based on observed weight loss and tolerance
Previously approved diabetes drugs were weight neutral or caused weight gain, a concern because obesity is often a co-morbidity of T2DM and can increase the risk for a cardiovascular complication, such as a heart attack or stroke
Managing Nausea with GLP-1 Medications While nausea can be a deterrent for continuing medication, several strategies can help manage and minimize this side effect
In murine models treated with the neurotoxin MPTP, which selectively targets dopaminergic neurons to simulate PD, semaglutide administration effectively safeguarded these neurons from apoptosis, maintained dopamine concentrations, and subsequently enhanced motor function ( 4.3 Cerebrovascular disease models Given the established association between vascular health and cognitive function, the effects of semaglutide on stroke models are of particular significance