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This mirrors broader healthcare trends toward digital-first solutions that expand reach without the friction of legacy systems

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Zanatta , Cecatto C, Ribeiro RT, Amaral AU, Wyse AT, Leipnitz G, Wajner M (2018) S-adenosylmethionine promotes oxidative stress and decreases Na+, K+-ATPase activity in cerebral cortex supernatants of adolescent rats: implications for the pathogenesis of S-adenosylhomocysteine hydrolase deficiency

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A key mechanism underlying this effect is the modulation of macrophage polarization