glp 1 effects on inflammation GLP-1 Drugs: For Multiple Chronic Conditions The role of GLP-1 RA

doi:10.1016/j.sleep.2019.01.022

Alleviating the unwanted effects of oxidative stress on A clearance: a review of related concepts and strategies for the development of computational modelling

What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology

L.HsiaoC

Glucocorticoids may inhibit growth hormone release by enhancing -adrenergic responsiveness in hypothalamic somatostatin neurons

Kaufman and Ruhoy have been reducing costs by having compounding pharmacies produce low-dose versions of them