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At higher quantities, mild hypotension and a temporary decrease in concentration have been described in individual observations, likely related to the sedative profile of the compound

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[9]Kabir AH, Das U, et al

A 2025 literature and patent review cataloged effects across many organ systems and called the preclinical base large for a single peptide

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Important safety considerations include a boxed warning for risk of thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and risks of pancreatitis, gallbladder disease, acute kidney injury with dehydration, and diabetic retinopathy complications with semaglutide