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The study on rhesus monkeys identified dose-dependent renal (kidney) toxicity as the primary limiting factor

Costa FRC, Franozo MCS, de Oliveira GG et al (2016) Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

The FDA also examines how oral semaglutide interacts with other medications and common medical conditions

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