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In PACs stimulated with cerulein and resistin, pro-inflammatory processes are activated, but -lipoic acid, via PPAR- activation, increases HO-1 and catalase expression, suppresses ROS and IL-6 levels, and thereby indicates functional integration of peroxisomal and mitochondrial antioxidant defenses ( This limitation is particularly relevant when extrapolating these findings to HTG-AP, because hyperlipidemic disease states impose continuous fatty acid excess and may shift the mitochondriaperoxisome relationship from adaptive cooperation to maladaptive overload

Diabetes 52 , 581587 (2003)

While not the primary reason for inclusion in weight loss protocols, this effect contributes to overall appearance improvements that accompany successful transformation

Anal Biochem 175 (2): 408-13