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Compared with other -omics approaches, such as transcriptomics and proteomics, the application of metabolomics in studying chronic conditions like ME/CFS, is still emerging

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These substances can activate key pro-inflammatory signaling pathways such as nuclear factor kappa B (NF-B), thereby inducing the gene transcription and protein secretion of extracellular matrix (ECM) degrading enzymes like matrix metalloproteinase 13 (MMP13) and A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 (ADAMTS5) (Zhang et al., 2023