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PubMed, Wang, Ping, et al

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The main driving force for the transport of some flavonoids and anthocyanins into vacuole has been inferred to be a proton gradient between the cytoplasm and the vacuole (or the cell wall), which is maintained by H + -ATPases (and H + -PPases in the tonoplast

larger mammals) Route of administration (oral vs

The process begins in the hypothalamus , a region of the brain that releases signaling molecules that communicate with the pituitary gland