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We have recently demonstrated the presence of angiotensin receptors on colonic afferent neurons 41 and consistent with the expression of these receptors on L cells 15 and sensory nerves, including nodose ganglion neurons 42,43 , a biphasic afferent response was observed in response to administration of AngII in afferent nerve recordings from intact colonic preparations

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The metabolic improvements seen with GLP-1sincluding better insulin sensitivity, reduced inflammation markers, and improved lipid profilesare particularly valuable during perimenopause when metabolic health often declines