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The prevalence of ANA rose between 1988 and 2012, but this upward trend was not linear, showing a relatively small increase from 19881991 to 1999-2004, followed by a much larger increase from 19992004 to 2011-2012

There could be a multitude of other health conditions associated with a white tongue, such as oral thrush, geographic tongue, mouth cancer, leukoplakia, tongue cancer, etc

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However, by the late 1970s, television smoking ads had been banned and antismoking campaigns and nonsmokers' rights groups became more prevalent, likely contributing to a decline in smoking