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doi: 10.3389/fendo.2018.00649 Received 19 June 2018 Accepted 15 October 2018 Published 06 November 2018 Volume 9 - 2018 Edited by Marco Falasca, Curtin University, Australia Reviewed by Marta Letizia Hribal, Universit degli studi Magna Grcia di Catanzaro, Italy

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While tirzepatide established superiority over semaglutide in the SURMOUNT-5 trialachieving 20.2% weight loss vs 13.7%indirect network meta-analyses suggest that retatrutide will likely surpass tirzepatide in both absolute and percentage weight reduction

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Foundayo is a newer oral GLP-1 option, which sets it apart from the injectable alternatives

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