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Loeffler M, Kruger JA, Niethammer AG, Reisfeld RA

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Being on any combination therapy early in the disease is associated with enduring advantages, sometimes termed "legacy effects," in which benefits lag behind for a while [39], [41]

Our study suggests that dysregulation of the renal tubular circadian clock could be an important aggravating factor or second hit in the progression of carnitine deficiency

doi: 10.1016/j.bbamcr.2016.09.012 19 HayesJDDinkova-KostovaATTewKD

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