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Rarely reported side effects include: Allergic reactions, leading to a rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing

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They were also advised to discontinue oral vitamin A, C, and E supplementation

Yao JK, Leonard S, Reddy R

J., Yu, R., Longo, J., Archer, M

Selective interactions of mu-opioid receptors with pertussis toxin-sensitive G proteins: involvement of the third intracellular loop and the c-terminal tail in coupling