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The rationale for this treatment schedule is based on two major premises: (a) the anti-inflammatory or therapeutic effect of corticoids persists longer than their physical presence and metabolic effects and (b) administration of the corticosteroid every other morning allows for re-establishment of more nearly normal hypothalamic-pituitary-adrenal (HPA) activity on the off-steroid day

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Replacing the Transporter T4 (1992, k19992003 EuroVan) in North America, the Routan was sold in the United States, Canada, and Mexico