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Nicotine gets most of the blame here, but its not acting alone

As nicotine leaves your system, your blood vessels begin to relax

Having considered further evidence, the Government has decided that a regulatory approach may be required to ensure that the industry takes sufficient financial responsibility for the litter created by its products and to prevent them from undermining public health policy

Just checked my on-line manual

Made For 1-4 Smokers

Nicotine can influence glutamate signaling, and while that can contribute to sharper focus in some people, it can also worsen symptoms in those who already feel wired but tired, overstimulated, anxious, restless, sound-sensitive, light-sensitive, or prone to insomnia