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A spokesperson for telemedicine platform Midi, which has been advertising GLP-1 microdoses on Instagram, said health risks from being overweight, like cardiovascular disease, can begin at BMIs lower than 27 and the shots have a range of benefits like improving fatty liver disease and easing sleep apnea symptoms

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Preclinical studies, small controlled trials, and observational research further suggest that GLP-1 receptor agonists may have beneficial effects in the prevention and treatment of mood disorders and in psychopathology domains that substantially impair quality of life, including cognitive dysfunction and anhedonia

The median follow-up was only 47 days, too short for most patients to lose enough weight to meaningfully alter their levothyroxine requirements through the weight-based mechanism alone

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