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In 2001 the Institute of Medicine, a subsidiary of the National Academy of Sciences, provided a now widely accepted definition of a harm reduction product as "harm reducing if it lowers total tobacco related mortality and morbidity even though use of that product may involve continued exposure to tobacco related toxicants" [15]

[6] Histological evaluation may reveal inclusion elements distributed in a lamellar fashion in the large axons of the optic nerve

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Every cigarette contains over 4,000 chemicals

21 (British Columbia Provincial Museum, Victoria, BC, Canada)