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For the other cancers, the rates in non-smokers are not known, and thus the usual formula for calculating the population attributable fraction (PAF) is used: where P e is the prevalence of exposure and r is the relative risk in smokers

While the benefits of quitting smoking are vast, long-term smoking (1020 years) can cause chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis or emphysema, from which the lungs never fully recover or heal

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To date, rodent vapor self-administration paradigms have been demonstrated to be less robust than intravenous self-administration