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So, its better to be overly cautious

1 2 "Levels of selected analytes in the emissions of "heat not burn" tobacco products that are relevant to assess human health risks"

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It's recommended that newer users start with a low dose of 2 mg or less

The risks of NVPs include: 100, 101 unknown long-term health effects intentional and accidental poisoning acute nicotine toxicity, injuries, burns and lung injury dual use with continued smoking 102 greater long-term exposure to nicotine than the use of other smoking cessation measures 103 diversion leading to use by non-smokers acting as a gateway to tobacco use the potential to promote nicotine use and re-normalise smoking among those who do not smoke, especially young people 104 Nicotine exposure can harm adolescent brain development 104 potential medicolegal risks for prescribers

For many, the discomfort becomes too much to bear, leading them back to smoking for relief