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119,133 The adverse GI effects are thought to be both central (direct action on GLP-1 receptors in the area postrema in the brainstem) and local (direct effect on the intestines)

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CrossRef Nitric oxide pathway: Emerging therapeutic strategies for MASLD Yanling Zhang, Ying Zhang, Hongjin Chen, Fangfang Qi Pathology - Research and Practice .2026

Moreover, women had a significantly increased likelihood of developing acne vulgaris after 1 year [79]