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The differential diagnosis for the most common presenting symptoms of IBDs (eg, abdominal pain) is broad, and it highlights the importance of a careful examination and diagnostic workup, with diagnosis based on a combination of clinical symptoms and results of serologic testing, imaging studies, endoscopy, and histopathology

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Nicotine in diseases Smoking inserts a high amount of xenobiotics, which in turn can alkylate DNA, activate specific (anti)inflammatory signals, and oxidative stress in active smokers and also second-hand smokers [167, 168]

(IARC Scientific Publications

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