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The effects normally last 3-4 hours but can last longer if the drug is eaten

Freebase Nicotine: At higher quantities, traditional "freebase" nicotinethe kind found in early e-cigarettescan cause a more severe throat hit

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Viloria T, Meseguer M, Martnez-Conejero JA et al (2010) Cigarette smoking affects specific sperm oxidative defenses but does not cause oxidative DNA damage in infertile men