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Smaller pets such as rabbits, rats, mice, and guinea pigs who live in smoking households are particularly affected by second-hand smoke, often suffering from lung cancer, pneumonia, and heart problems

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Although IL-18 knockout mice exhibit reduced pulmonary inflammation and emphysema compared to wild-type mice after cigarette smoke [21, 24], pulmonary inflammation occurred independent of NLRP3/caspase-1 axis after four weeks of cigarette smoke exposure [25]