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[71] found that the expression of protein arginine methyltransferase 6 (PRMT6) and asymmetric di-methylation of histone H3 arginine 2 (H3R2me2a) were significantly decreased in the lung tissues of patients with COPD who continue to smoke and CSE-induced mice

It is believed that tobacco use has a detrimental impact on individuals, countries, and nations health and economy 21

Nearly two thirds of current vapers are ex-smokers (64.6%), and the proportion continues to grow, while the proportion who also smoke (known as dual users) has fallen to 30.5% in 2021

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