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The Surgeon General's Warning released in 1964 was a major impetus for this change

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And if you remove the ones that have been supported by the makers of the nicotine-delivery devices, theres really not adequate evidence that e-cigarettes are beneficial. For now, the FDA has funded 48 research projects to find out more

Three risk factors were identified for laryngeal cancer mortality and DALY, including alcohol use, tobacco use, and occupational risk

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Main characteristics of the studies are presented in Table 1