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Key translational gaps therefore include determining which lactylation events are truly required drivers in vivo rather than by-products, resolving the spatial and directional relationships among lactate sources, lactylation deposition and immunosuppressive/invasive phenotypes, and establishing quantitative thresholds and stratification criteria to enable rational combination strategies (for example with immunotherapy or anti-metastatic regimens) without broadly compromising anti-tumor immune metabolism

Appelhoff, R

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The BDF-L group showed no significant difference from the FC group

This discrepancy may be due to the specific characteristics of the study population or duration of the intervention