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CO prevents the maturation of dendritic cells and lowers the production of pro-inflammatory cytokines and the proliferation of effector T cells, whereas it stimulates the secretion of the anti-inflammatory cytokine IL-10 which may explain the beneficial effects in UC [51]

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Due to their different focus and aims, species-level extinction assessments and assemblage-level biodiversity analyses are pursued largely in isolation, and sometimes reveal hard to reconcile patterns of change 30 for instance, elevated global extinction rates alongside a mix of population and diversity trends at smaller scales 6,23,24,25,27,31 In addition, studies evaluating broad-scale patterns of extinction risk mostly focus on individual populations, on particular taxa or use proxies to estimate extinction risk 4,11,14,16,26,32,33

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