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According to the American Lung Association, nicotine reaches the brain within 10 seconds of inhalation, which is part of why smoked tobacco creates such strong dependence the rapid delivery reinforces the habit loop far more efficiently than slower-release formats [2]

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Front Sens 657931:124 Schleif F, Hammer B, Monroy J, Jimenez J, Blanco-Claraco J, Biehl M (2015) Odor recognition in robotics applications by discriminative time-series modeling

The name M81 is no coincidence, by the way