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The denominator is the difference between the smokers and nonsmokers reference lung cancer death rates

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Loss of Lung Function Smoking eventually causes emphysema, a disease where air sacs in the lungs are damaged and breathing becomes increasingly difficult

Coffee and Caffeine Genetics Consortium, CornelisMCByrneEMEskoTNallsMAGannaAet alGenome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption