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An in vitro assay using epithelial cells (AMOL-III) from the oral leukoplakia of a Khaini user and treatment with aqueous extract of Khaini showed alteration in the expression of proteins involved in cell cycle regulation and DNA methylation, suggesting the role of Khaini in oral carcinogenesis (Rohatgi et al., 2005)

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For many, it's not a matter of "guessing" whether or not a foreign chemical is present and at work inside their brain

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I know, see, cause Im the guy was giving her the push. He pointed his cigar at himself