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COMMENTARY Nicotinamide is marketed as a nicotine substitute for e-cigarettes In October 2023, the major e-cigarette supplies wholesaler, Nicotine River, known for sales of bulk nicotine, solvents, and flavors, began sales of a nicotine substitute with the brand name Nixamide, a name trademarked by the company Ready Mix Naturals, LLC, and with the main active ingredient being Nicotinamide 4

While consumption remains largely unchanged, consumers get pushed to illicit markets that often have more dangerous products and prop up sophisticated organized criminal enterprises supplying their demand