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James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH et al

Fibroblasts stimulated with TGF- show increased glutaminolysis, which contributes to increased -KG content (224)

These results indicate that glutathione is critical for both mammalian development and homeostasis

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Microglia, astrocytes, and infiltrating macrophages remain chronically activated and secrete neurotoxic factors, while dysfunctional oligodendrocytes and Schwann cells fail to uphold myelin and metabolic support