For combustible tobacco cigarettes, smoking is understood to be a complex process that allows smokers to titrate their desired dose of nicotine and nicotine brain level on a puff-by-puff basis
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Box 50-1 Evidence-Based Relationship between Smoking and Disease From US Surgeon General
The researchers also found that 4% of e-cigarette users had switched to a high-nicotine concentration in 2019, a rate nearly double that of 2017 (2.2%)