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Some papers included a more comprehensive set of covariates addressing plausible shared risk factors across demographic, environmental, and intrapersonal/endogenous dis-positional domains, providing a more rigorous evaluation of the degree to which an observed association between e-cigarette use and subsequent smoking is direct (i.e., not due to confounding), whereas some included demographic factors and excluded important environmental or intrapersonal factors

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In addition to the potential physiologic risks of vaping, the nicotine and non-nicotine compounds inhaled in electronic cigarette smoke are associated with cellular injury and immune cell activation

Cell 166 , 555566 (2016)

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