In participants with serum cotinine levels between 0.05 and 2.99 ng/mL, fecal frequency-related constipation was positively associated with serum cotinine after adjusting for confounders
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Smokeless tobacco Smokeless tobaccocomposed of fermented plant materials, alkaline additives (e.g., sodium carbonate), and carcinogenic nitrosaminesdiffers fundamentally from combustible cigarettes and aerosolized ECs by delivering nicotine and toxins through direct mucosal contact rather than inhalation, a distinction that reshapes its biological interactions and uniquely perturbs oral microbial ecosystems through pH modulation, xenobiotic exposure, and epithelial barrier disruption
peering bleary-eyed at the apartment building across the lanewith the same three apartments always bathed in light, their occupants wide awakewondering if they were sobbing and dead inside like me