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Most robust data concern cigarette smoking

Tobacco smoking reduces p53, a tumor suppressor gene that is considered the genome guardian. Suppression of T-cell responses by Nicotine and tar is associated with decreased surveillance for tumor cells] reported that heavy smokers accumulate excess iron in hepatocytes which induces fibrosis and favors the development of HCC

PMID 7866221

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Contribution of Adipose Tissue Lipolysis to Nicotine and HFD-Induced Hepatic Steatosis Adipose tissue has the unique function of storing TG in lipid droplets and upon lipolysis, to provide FFA to other organs during time of energy shortage (47)