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Coordinated public health interventions, regulatory enforcement, and continued research are essential to prevent nicotine dependence and protect the wellbeing of future generations

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These carcinogens undergo metabolic detoxification catalyzed by a variety of enzymes such as glutathione-S-transferases (GSTs), uridine-5-disphosphate-glucuronosyltransferases (UGTs), epoxide hydrolases, and sulfatases